What is gene ontology?
Gene ontologies are the set of vocabularies that represent gene product properties. These terms cover three domains: cellular component, molecular function, and biological process [1].
- Cellular component: these terms describe the parts of a cell or its extracellular environment, such as the nucleus, or a gene product group, like ribosomes.
- Biological process: this term describes the series of molecular events that are important for total biological functioning.
- Molecular function: this term describes the activities that occur at the molecular level, such as binding activity [1].
What is the gene ontology of TP53?
Cellular component:
TP53 is localized to the nucleus in many tissues throughout the body, not including muscle and adipose tissues.
TP53 is localized to the nucleus in many tissues throughout the body, not including muscle and adipose tissues.
Biological Processes:
TP53 is involved in a large number biological processes. The main processes include: regulation of transcription, apoptotic processes, and protein tetramerization.
Molecular Function:
TP53 is also involved in a wide variety of molecular functions, including: DNA binding, transcription factor activity, protein binding, and transcription regulatory region DNA binding [2].
TP53 is involved in a large number biological processes. The main processes include: regulation of transcription, apoptotic processes, and protein tetramerization.
Molecular Function:
TP53 is also involved in a wide variety of molecular functions, including: DNA binding, transcription factor activity, protein binding, and transcription regulatory region DNA binding [2].
Conclusion:
TP53 has an extremely large variety of gene ontologies, thus making it a complex gene of interest for research. Because it has so many functions and exists in so many tissues, it is key to have a narrow research focus in order to avoid having too many variables to look at. This wide range of gene ontologies also pays homage to TP53's wide and important role in the human body and in human diseases.
TP53 has an extremely large variety of gene ontologies, thus making it a complex gene of interest for research. Because it has so many functions and exists in so many tissues, it is key to have a narrow research focus in order to avoid having too many variables to look at. This wide range of gene ontologies also pays homage to TP53's wide and important role in the human body and in human diseases.
References:
[1] The Gene Ontology Consortium. Ontology Documentation. Retrieved February 14, 2017. http://geneontology.org/page/ontology-documentation
[2] Interpro EMBL-EBI. (2017). InterPro. Retrieved February 14, 2017. http://www.ebi.ac.uk/interpro/
[1] The Gene Ontology Consortium. Ontology Documentation. Retrieved February 14, 2017. http://geneontology.org/page/ontology-documentation
[2] Interpro EMBL-EBI. (2017). InterPro. Retrieved February 14, 2017. http://www.ebi.ac.uk/interpro/